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and female athletes across different events and sports that emphasize either endurance and aerobic fitness (for longer distance events) or anaerobic capacities (for short-distance, sprint events) Significant evidence exists that there are genetic limits with respect to anaerobic activities, but less consistent evidence for limits in aerobic capacities (eg, Bouchard et al, 1990; Simoneau et al, 1986) Analyses of swimmers and triathletes showed that for the longer events, practice was significantly related to performance times, but that gender did not make a significant contribution to the regression model However, examination of the sprint events in swimming showed that although 20% to 30% of the variance in these events could be accounted for by practice, it was not a significant predictor Gender accounted significantly for 30% to 40% of the variance in performance times even after controlling for practice.

5 DISCUSSION 51 Tissue-Engineered Vascular Grafts In this chapter we have described a biodegradable scaffold-based method of tissue engineering blood vessels with mechanical and functional properties that approach the requisite properties for clinical application Our constructs, grown under pulsatile conditions, possess many of the physiological and mechanical characteristics of native arteries, including burst strengths of more than 2000 mmHg provided entirely by the medial layer As our technique also emphasizes the creation of a functional endothelium, we have been the rst to implant autologous tissueengineered arteries that have remained patent and functional for up to 4 weeks Despite these exciting and promising accomplishments, many hurdles remain on the road to creating a fully functional tissue-based vascular graft The design of a functional nerve and microvascular supply in vitro to support the vascular tissue remains elusive.

Although perhaps not an essential requirement for vascular conduits, achieving their production would mark a signi cant leap forward in the eld of tissue engineering 52 Genetic Manipulation in Tissue-Engineered Blood Vessels To create functional vascular grafts that mimic the native vasculature as closely as possible, the in vitro loss of optimal cell phenotype will need to be addressed Endothelial cells in culture, for example, are known to downregulate the expression of many anticoagulant and anti-in ammatory molecules that are expressed on the native, quiescent endothelium [Wu and Thiagarajan, 1996] Unfortunately, many procoagulant and proin ammatory molecules including tissue factor, vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) are instead upregulated during culture [Carlos and Harlan, 1994; Lin et al, 1997; Allen et al, 1998].

Thus it appears likely that cultured endothelial cells seeded onto the lumen of tissue-engineered blood vessels exhibit a procoagulant rather than antithrombogenic phenotype, ultimately contributing to graft failure due to thrombosis Not unexpectedly, the critical limitation in the successful.

persistence) and with different affective and cognitive responses in performance situations (see recent review by Duda, 2005, as well as 1 by Roberts, Treasure, & Conroy in this Handbook) A primary issue for the current chapter is the degree to which the goal orientation that parents assume for their child s sport or physical activity participation affects the child s beliefs and values as well as her or his performance and behavior The few research studies that have been conducted in the sport area have indicated that there is a positive and significant correlation between parents and children s achievement goal orientations For example, Duda and Hom (1993) assessed the goal orientations of children (8 to 15 years) attending a summer basketball camp In addition, these researchers assessed parents own self-reported goal orientations as well as children s perceptions of their parents goal orientations.

Remark If the channel is used without feedback [i.e., if the input symbols do not depend on the past output symbols, namely, p(xk |x k 1 , y k 1 ) = p(xk |x k 1 )], the channel transition function for the nth extension of the discrete memoryless channel reduces to

The fact that gender predicted performance for athletes in the two fastest events suggests that enduring physical differences between individuals, as a result of gender, limit performance for activities with high anaerobic demands that appear to be less amenable to training Other efforts to examine gender differences have been conducted by Duffy, Baruch, and Ericsson (2004) in a sport that ostensibly appears to have very little physical attribute advantages, that is, darts Despite controlling for variables such as arm length, age, years of experience, and the size of the recruitment pool where men and women were selected, performance differences across male and female players were observed It was concluded that, barring other variables, such as spatial abilities, practice time and quality are the main variables that differentiate gender, although no specific examination of this hypothesis was conducted.